

It ranges from “automatic” to “infuriating”.
If you have Secure Boot enabled, there are some hoops to jump through. Read the docs and follow the steps for DKMS.
Depending on your distro and your requirements, you might want to install the drivers manually from Nvidia rather than using older drivers from your distro.
If you need CUDA, god help you. Choose a distro that makes this easy and use containers to avoid dependency hell. Note that this is not any easier on Windows (at least not last I checked, which was a few years ago).
There are two potential show-stoppers.
Field-specific apps that only run on windows. If you really need Adobe Creative Cloud or SolidWorks or something like that you might be out of luck. This is mostly true for apps that require GPU acceleration, which is difficult to rig up in a VM. You wouldn’t want to do that if it was a big part of your workload.
Mandatory spyware and rootkit DRM to prevent cheating with remote tests. Hopefully if they do such a thing they provide loaner hardware too. I’ve seen a lot of bullshit in my time but my experience is outdated, so I don’t know what’s common nowadays.